Assessment of hepatic function employing hepatocyte specific contrast agent concentrations to multifactorially evaluate fibrotic remodeling
نویسندگان
چکیده
Background: Diffuse parenchymal liver diseases are contributing substantially to global morbidity and represent major causes of deaths worldwide. The aim our study is assess whether established hepatic fat iron quantitation relaxometry-based quantification hepatocyte-specific contrast material as surrogate for function estimation allows evaluate fibrosis.
منابع مشابه
Hepatocyte-Specific Contrast-enhanced MRI for Quantitative Assessment of Liver Function in Children
Objectives: The liver is a complex, multifunctional organ involved in a variety of critical processes. Accurate determination of liver function in children is difficult and current biomarkers often fail to truly assess functional capacity. Advances in magnetic resonance imaging (MRI) with hepatocyte-specific, gadolinium-based agents have enabled improved liver imaging. Since a functional hepato...
متن کاملHepatocyte-specific contrast agent-enhanced magnetic resonance cholangiography: perioperative evaluation of the biliary tree
A large number of gadolinium chelates have recently been tested in clinical trials. Some of those have already been approved for clinical use in the United States and Europe. Thus, new diagnostic perspectives have been incorporated into magnetic resonance imaging studies. Among such gadolinium chelates are hepatobiliary-specific contrast agents (HSCAs), which, due to their property of being sel...
متن کاملSupradiaphragmatic Liver Confirmed by a Hepatocyte-specific Contrast Agent (Gd-EOB-DTPA): A Case Report
Supradiaphragmatic liver is a rare condition. Establishing an accurate preoperative diagnosis is difficult. Operative exploration is necessary to differentiate this lesion from intrathoracic masses, such as a pleural based tumor, diaphragmatic tumor and peripheral lung tumor. However, with the aid of the hepatocyte-specific magnetic resonance imaging contrast agent, gadoxetic acid (Gd-EOB-DTPA)...
متن کاملHepatocyte Growth Factor Isoforms in Tissue Repair, Cancer, and Fibrotic Remodeling
Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleotropic factor required for normal organ development during embryogenesis. In the adult, basal expression of HGF maintains tissue homeostasis and is up-regulated in response to tissue injury. HGF expression is necessary for the proliferation, migration, and survival of epithelial and endothelial cells involved in tissue ...
متن کاملCollagen-specific peptide conjugated HDL nanoparticles as MRI contrast agent to evaluate compositional changes in atherosclerotic plaque regression.
OBJECTIVES This study sought to develop magnetic resonance contrast agents based on high-density lipoprotein (HDL) nanoparticles to noninvasively visualize intraplaque macrophages and collagen content in mouse atherosclerotic plaques. BACKGROUND Macrophages and collagen are important intraplaque components that play central roles in plaque progression and/or regression. In a Reversa mouse mod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Quantitative imaging in medicine and surgery
سال: 2023
ISSN: ['2223-4292', '2223-4306']
DOI: https://doi.org/10.21037/qims-22-884